Insulin: route of administration | The poor, misunderstood calorie

The basic biology of endogenous insulin secretion makes sense, physiologically/geographically.

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It slams the liver first, which sees more concentrated insulin than any other tissue. By the time insulin reaches the periphery, a lot has already been cleared and it’s been considerably diluted by peripheral blood.

This makes sense because liver does a lot of the heavy lifting wrt blood glucose control. The first phase insulin secretion and all that jazz.

Skeletal muscle (SkM) and adipose tissue (AT) see just enough to enhance glucose clearance and slow down lipolysis.

Enter: new insulin analogs.

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Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. Use discount code LAGAKOS for a deal on CarbonShades. If you have no idea what I’m talking about, read this then this.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

20% off some delish stocks and broths from Kettle and Fire HERE

Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

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Ketogenic diet in alcohol withdrawal

Ketogenic diet reduces alcohol withdrawal symptoms in humans and alcohol intake in rodents (Wiers et al., 2021)

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First, the bad news: it appears they totally botched the rat study. Fed half of ’em a standard diet and the other half a ketogenic diet for a couple months, then exposed half in each group to alcohol (in the air) for a few weeks to induce dependence, then…

Hold up. Rats on this ketogenic diet failed to thrive. Big confounder. Every college kid knows why…

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Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. Use discount code LAGAKOS for a deal on CarbonShades. If you have no idea what I’m talking about, read this then this.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

20% off some delish stocks and broths from Kettle and Fire HERE

Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

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One MAD, Two MAD, | The poor, misunderstood calorie

Red MAD, Blue MAD.

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OMAD = One Meal A Day. AKA skipping breakfast & lunch then having a huge dinner. Don’t @ me “I break my fast at 6pm!” It’s still called dinner.

It’s a fairly rare practice, although both low carb OMAD & high carb OMAD groups have their respective echo chambers on social media. I said respective, not respectful

Both groups also claim their method makes this type of fasting more tolerable, but I have doubts… in general (not OMAD), studies don’t show systematic differences in adherence/attrition/drop outs on HC vs. LC. But there are anecdotes, and that’s fine.

My only qualms (aside from the logical fallacy thing about how the people who don’t achieve success with a particular diet usually just move on to something else, whereas those who do tend to be very loud about it online)…

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Affiliate links: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. Use discount code LAGAKOS for a deal on CarbonShades. If you have no idea what I’m talking about, read this then this.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

20% off some delish stocks and broths from Kettle and Fire HERE

Real Mushrooms makes great extracts. 10%…

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Postprandial glucose variability and reward centers of the brain. What now?

IT DID NOT INCREASE HUNGER 

*phew* had to get that off my chest

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A couple new studies making the rounds on social media. Being misinterpreted, or misunderstood, or just lied about. So, just another Tuesday

Tweet thread. Might be more succinct, Idk: https://twitter.com/CaloriesProper/status/1390471095652847617

Diets Varying in Carbohydrate Content Differentially Alter Brain Activity in Homeostatic and Reward Regions in Adults (Ebbeling, Holsen, Ludwig, et al., 2021)

Fancy methodology. In brief: 20-week weight loss diet, either high carb (60%), moderate carb (40%), or low carb (20%). Then during weight maintenance, they were brought in to have blood flow to specific brain regions before and after a meal of their respective diet.

They were focusing on “reward” centers of the brain, to see if any of these regions are hyper-activated by specific macronutrients (ie, carbs). And I’ll admit, the authors did just as much to lead the readers to their desired interpretation as did the people yelling about this study on Twitter.

For the rest of this article and more, head over to Patreon! Five bucks a month for access to this and all previous articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks 

For personalized health consulting services: [email protected].

Affiliate links: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. Use discount code LAGAKOS for a deal on CarbonShades. If you have no idea what I’m talking about, read this then this.

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Intranasal insulin. Interesting. | The poor, misunderstood calorie

This has appeared off & on in the literature for some time now.

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Brain insulin signaling is a real thing. There appears to be two components: insulin produced in situ (within the brain) and acting on brain/neuronal insulin receptors; and insulin signaling in the brain induced by peripheral/pancreatic insulin.

It isn’t known if pancreatic insulin physically crosses into the brain, although it appears as though insulin increases in CSF after a meal.

For the rest of this article and more, head over to Patreon! Five bucks a month for access to this and all previous articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks 

For personalized health consulting services: [email protected].

Affiliate links: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. Use discount code LAGAKOS for a deal on CarbonShades. If you have no idea what I’m talking about, read this then this.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

20% off some delish stocks and broths from Kettle and Fire HERE

Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

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“Forced energy restriction.” Nice one, spin doctors.

Spin doctor – A person who publicizes favorable interpretations of the words and actions of a public figure (or in this case, a diet).

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New study on low carb diets for diabetes. Surprise, surprise, HbA1c reduction paralleled weight loss in the short- & long-term.

I love me some low carb diet research, but this was a bad interpretation/spin of the study results:

Here’s why…

For the rest of this article and more, head over to Patreon! Five bucks a month for access to this and all previous articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks 

For personalized health consulting services: [email protected].

Affiliate links: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. Use discount code LAGAKOS for a deal on CarbonShades. If you have no idea what I’m talking about, read this then this.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

20% off some delish stocks and broths from Kettle and Fire HERE

Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

calories proper

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