Insulin: route of administration | The poor, misunderstood calorie

The basic biology of endogenous insulin secretion makes sense, physiologically/geographically.

[Patron link]

It slams the liver first, which sees more concentrated insulin than any other tissue. By the time insulin reaches the periphery, a lot has already been cleared and it’s been considerably diluted by peripheral blood.

This makes sense because liver does a lot of the heavy lifting wrt blood glucose control. The first phase insulin secretion and all that jazz.

Skeletal muscle (SkM) and adipose tissue (AT) see just enough to enhance glucose clearance and slow down lipolysis.

Enter: new insulin analogs.

For the rest of this article and more, head over to Patreon! Five bucks a month for access to this and all previous articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks 

For personalized health consulting services: [email protected].

Affiliate links: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. Use discount code LAGAKOS for a deal on CarbonShades. If you have no idea what I’m talking about, read this then this.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

20% off some delish stocks and broths from Kettle and Fire HERE

Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

calories proper

This entry was posted in Uncategorized. Bookmark the permalink.

Continue reading

Ketogenic diet in alcohol withdrawal

Ketogenic diet reduces alcohol withdrawal symptoms in humans and alcohol intake in rodents (Wiers et al., 2021)

[Patron link]

First, the bad news: it appears they totally botched the rat study. Fed half of ’em a standard diet and the other half a ketogenic diet for a couple months, then exposed half in each group to alcohol (in the air) for a few weeks to induce dependence, then…

Hold up. Rats on this ketogenic diet failed to thrive. Big confounder. Every college kid knows why…

For the rest of this article and more, head over to Patreon! Five bucks a month for access to this and all previous articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks 

For personalized health consulting services: [email protected].

Affiliate links: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. Use discount code LAGAKOS for a deal on CarbonShades. If you have no idea what I’m talking about, read this then this.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

20% off some delish stocks and broths from Kettle and Fire HERE

Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

calories proper

This entry was posted in Uncategorized. Bookmark the permalink.

Continue reading

One MAD, Two MAD, | The poor, misunderstood calorie

Red MAD, Blue MAD.

[Patron link]

OMAD = One Meal A Day. AKA skipping breakfast & lunch then having a huge dinner. Don’t @ me “I break my fast at 6pm!” It’s still called dinner.

It’s a fairly rare practice, although both low carb OMAD & high carb OMAD groups have their respective echo chambers on social media. I said respective, not respectful

Both groups also claim their method makes this type of fasting more tolerable, but I have doubts… in general (not OMAD), studies don’t show systematic differences in adherence/attrition/drop outs on HC vs. LC. But there are anecdotes, and that’s fine.

My only qualms (aside from the logical fallacy thing about how the people who don’t achieve success with a particular diet usually just move on to something else, whereas those who do tend to be very loud about it online)…

For the rest of this article and more, head over to Patreon! Five bucks a month for access to this and all previous articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks 

For personalized health consulting services: [email protected].

Affiliate links: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. Use discount code LAGAKOS for a deal on CarbonShades. If you have no idea what I’m talking about, read this then this.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

20% off some delish stocks and broths from Kettle and Fire HERE

Real Mushrooms makes great extracts. 10%…

Continue reading

Postprandial glucose variability and reward centers of the brain. What now?

IT DID NOT INCREASE HUNGER 

*phew* had to get that off my chest

[Patron link]

A couple new studies making the rounds on social media. Being misinterpreted, or misunderstood, or just lied about. So, just another Tuesday

Tweet thread. Might be more succinct, Idk: https://twitter.com/CaloriesProper/status/1390471095652847617

Diets Varying in Carbohydrate Content Differentially Alter Brain Activity in Homeostatic and Reward Regions in Adults (Ebbeling, Holsen, Ludwig, et al., 2021)

Fancy methodology. In brief: 20-week weight loss diet, either high carb (60%), moderate carb (40%), or low carb (20%). Then during weight maintenance, they were brought in to have blood flow to specific brain regions before and after a meal of their respective diet.

They were focusing on “reward” centers of the brain, to see if any of these regions are hyper-activated by specific macronutrients (ie, carbs). And I’ll admit, the authors did just as much to lead the readers to their desired interpretation as did the people yelling about this study on Twitter.

For the rest of this article and more, head over to Patreon! Five bucks a month for access to this and all previous articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks 

For personalized health consulting services: [email protected].

Affiliate links: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. Use discount code LAGAKOS for a deal on CarbonShades. If you have no idea what I’m talking about, read this then this.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 



Continue reading

Intranasal insulin. Interesting. | The poor, misunderstood calorie

This has appeared off & on in the literature for some time now.

[Patron link]

Brain insulin signaling is a real thing. There appears to be two components: insulin produced in situ (within the brain) and acting on brain/neuronal insulin receptors; and insulin signaling in the brain induced by peripheral/pancreatic insulin.

It isn’t known if pancreatic insulin physically crosses into the brain, although it appears as though insulin increases in CSF after a meal.

For the rest of this article and more, head over to Patreon! Five bucks a month for access to this and all previous articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks 

For personalized health consulting services: [email protected].

Affiliate links: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. Use discount code LAGAKOS for a deal on CarbonShades. If you have no idea what I’m talking about, read this then this.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

20% off some delish stocks and broths from Kettle and Fire HERE

Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

calories proper

This entry was posted in Uncategorized. Bookmark the permalink.

Continue reading

“Forced energy restriction.” Nice one, spin doctors.

Spin doctor – A person who publicizes favorable interpretations of the words and actions of a public figure (or in this case, a diet).

[Patron link]

New study on low carb diets for diabetes. Surprise, surprise, HbA1c reduction paralleled weight loss in the short- & long-term.

I love me some low carb diet research, but this was a bad interpretation/spin of the study results:

Here’s why…

For the rest of this article and more, head over to Patreon! Five bucks a month for access to this and all previous articles. 16% off for annual subscriptions! It’s ad-free and you can cancel if it sucks 

For personalized health consulting services: [email protected].

Affiliate links: OMAHA. STEAKS. Check here for daily discounts and the best steaks of your life.

Still looking for a pair of hot blue blockers? TrueDark is offering 10% off HERE and Spectra479 is offering 15% off HERE. Use discount code LAGAKOS for a deal on CarbonShades. If you have no idea what I’m talking about, read this then this.

Naked Nutrition makes some great products, including Naked Grass Fed Protein. Also, free shipping 

20% off some delish stocks and broths from Kettle and Fire HERE

Real Mushrooms makes great extracts. 10% off with coupon code LAGAKOS. I recommend Lion’s Mane for the brain and Reishi for everything else

calories proper

This entry was posted in Uncategorized. Bookmark the permalink.

Continue reading

Why excess abdominal fat is more DEADLY than you think

Below is an article contributed by Mike Geary, the founder of TruthAboutAbs.com .  I thought this was an important topic to share with you because the reality is that most people simply don’t realize how dangerous their excess abdominal fat really is to their health.

The Hidden Dangers of Your Excess Abdominal Fat – It’s More Serious Than a Vanity Issue!

by Mike Geary, Certified Nutrition Specialist, Certified Personal Trainer

Did you know that the vast majority of people in this day and age have excess abdominal fat? The first thing that most people think of is that their extra abdominal fat is simply ugly, is covering up their abs from being visible, and makes them self conscious about showing off their body.

However, what most people don’t realize is that excess abdominal fat in particular, is not only ugly, but is also a dangerous risk factor to your health. Scientific research has clearly demonstrated that although it is unhealthy in general to have excess body fat throughout your body, it is also particularly dangerous to have excess abdominal fat.

There are two types of fat that you have in your abdominal area. The first type that covers up your abs from being visible is called subcutaneous fat and lies directly beneath the skin and on top of the abdominal muscles.

The second type of fat that you have in your abdominal area is called visceral fat, and that lies deeper in the abdomen beneath your muscle and surrounding your organs. Visceral fat also plays a role in giving certain men that “beer belly” appearance where their abdomen protrudes excessively but at the same time, also feels sort of hard if you push on it.

Both subcutaneous fat and visceral fat in the abdominal area are serious health risk factors, but science has shown that having excessive visceral fat is even more dangerous than subcutaneous fat. Both of them greatly increase the risk your risk of developing heart disease, diabetes, high blood pressure, stroke, sleep apnea, various forms of cancer, and other degenerative diseases.

Part of the reason visceral fat is particularly dangerous is that it apparently releases more inflammatory molecules into your body on a consistent basis.

If you care about the quality of your life and your loved ones, reducing your abdominal fat should be one of your TOP priorities! There’s just no way around it. Besides, a side-effect of finally getting rid of all of that excessive ugly abdominal fat is that your stomach will flatten out, and if you lose enough stomach fat, you will be able to visibly see those sexy six pack abs that everyone wants.

So what gets rid of extra abdominal fat? Is there actually a REAL solution beyond all of the gimmicks and hype that you see in ads and on commercials for “miracle” fat loss products?

The first thing you must understand is that there is absolutely NO quick fix solution. There are no pills or supplements of any sort that will help you lose your abdominal fat faster. Also, none of the gimmicky ab rockers, rollers, or ab belts will help get rid of abdominal fat either. You can’t spot reduce your stomach fat by using any of these worthless contraptions. It simply doesn’t work that way.

The ONLY solution to consistently lose your abdominal fat and keep it off for good is to combine a sound nutritious diet full of unprocessed natural foods with a properly designed strategic exercise program that stimulates the necessary hormonal and metabolic response within your body. Both your food intake as well as your training program are important if you are to get this right.

I’ve actually even seen a particular study that divided thousands of participants into a diet-only group and an exercise/diet group. While both groups in this study made good progress, the diet-only group lost significantly LESS abdominal fat than the diet & exercise combined group.

Now the important thing to realize is that just any old exercise program will not necessarily do the trick. The majority of people that attempt getting into a good exercise routine are NOT working out effectively enough to really stimulate the loss of stubborn abdominal fat. I see this everyday at the gym.

Most people will do your typical boring ineffective cardio routines, throw in a little outdated body-part style weight training, and pump away with some crunches and side bends, and think that they are doing something useful for reducing their abdominal fat. Then they become frustrated after weeks or months of no results and wonder where they went wrong.

Well, the good news is that I’ve spent over a decade researching this topic, analyzing the science, and applying it “in the trenches” with myself as well as thousands of my clients from all over the world to see what works to really stimulate abdominal fat loss.

The entire solution… all of the nutritional strategies, as well as training sequences, exercise combinations, and more have all been compiled in my Truth About Six Pack Abs Program.

Keep in mind that the point of this whole program is NOT abdominal exercises (that is only a very small portion of it). The main point of this program is showing you the absolute most effective strategies for losing your stubborn abdominal fat, so you can get rid of that dangerous health risk, as well as get a flatter more defined midsection.

If you follow the guidelines, you WILL lose your belly fat that has been plaguing you for years. This is not guesswork… it is a proven system that works time and time again for all of my clients on every corner of the globe that actually apply the information I teach. If you apply it, the results will come. It’s really that simple.

The only reason most people fail in their fitness goals is that they have good intentions at first to adopt a new lifestyle, yet after a few weeks or months, they abandon their good intentions and slip right back into their old bad habits that gave them the excess body fat in the first place.

I want to help you succeed in finally getting rid of that extra abdominal fat that is not only UGLY, but also DANGEROUS.

Don’t waste another day allowing that nasty abdominal fat to kill your confidence as well as contribute to your risk for MAJOR diseases.

Get the solution to rid yourself for life of this problem at…

http://www.truthaboutabs.com/

Train hard, eat right, and enjoy life!